Bu kaydın yasal hükümlere uygun olmadığını düşünüyorsanız lütfen sayfa sonundaki Hata Bildir bağlantısını takip ederek bildirimde bulununuz. Kayıtlar ilgili üniversite yöneticileri tarafından eklenmektedir. Nadiren de olsa kayıtlarla ilgili hatalar oluşabilmektedir. MİTOS internet üzerindeki herhangi bir ödev sitesi değildir!

Nadir bir geçici iskemik atak nedeni: nörobrusellozis

Oluşturulma Tarihi: 2003

Niteleme Bilgileri

Tür: Makale

Yayınlanma Durumu: Yayınlanmış

Dosya Biçimi: PDF

Dil: İngilizce

Yazar(lar): BİNGÖL, Ayşe (Yazar),

Emeği Geçen(ler):

DOI: 10.1501/0001016

URL: NULL

Diğer Niteleme Bilgileri: http://acikarsiv.ankara.edu.tr/browse/3819/1281.pdf


Yayın Adı: JOURNAL OF ANKARA MEDICAL SCHOOL Yayın Tarihi: 2003 Sayı: 3 Cilt: 25 Yayınlandığı Sayfalar: 119-126 Yayın Niteleme Bilgileri: issn:1300-5464


Dosya:
file show file
Görüntüle
download file
Kaydet

Anahtar Kelimeler Transient İschemic Attack, İschemic Stroke,Geçici İskemik Atak, İskemik Strok, Brusellozis
Özet Incidence of neurologic complications in systemic brucellosis has been reported as 2-10%. Neurobrucellosis (NB) can mimic many central and peripheral nervous system disorders including transient ischemic attacks (TIA), and ischemic or hemorrhagicstroke. We report a series of four cases presented with TIA or ischemic stroke as the predominant manifestation of NB. Three of the patients were 20-28 years of age, and one patient was 53 years old. They did not possess any stroke risk factors except for smoking. They all used to consume pasteurized milk or its products. Two patients hadsystemic brucellosis in the past and received antibiotic treatment. All of the patients had systemic symptomssuch as headache, fatigue, anorexia, nausea and vomiting, weight loss or lumbar pain, but no systemicsigns of brucellosis accompanying ischemic cerebral symptoms. The second most frequent neurological sign was sensorineural hearing loss. Other causes of TIA including cardiac embolism, hypercoagulability,vascular malformations, systemic vasculitis, and infective endocarditis were excluded. NB was diagnosed with serological tests or cultures for Brucella in CSF. All patients were treated with rimethoprimsulfamethoxazole,doxycycline and rifampicin for at least six months. None of them had any further TIA after the initiation of the treatment NB should always be sought in young patients with TIA or ischemic stroke, especially if they have no risk factors for stroke and live in an endemic area for brucellosis, even if they do not have other systemic signs of brucellosis.
İçindekiler
Açıklamalar Sistemik brusellozda nörolojik komplikasyonların insidansı %2-10 olarak bildirilmektedir. Nörobrusellozis(NB), geçici iskemik atak (TİA), iskemik veya hemorajik strok da dahil pek çok santral ve periferik sinir sistemi hastalığını taklit edebilir.NB'un önde gelen belirtisi olarak TİA veya iskemik stroklu 4 hastalık bir seri bildiriyoruz. Üç hastanın yaşı20-28 arasında idi, birinin yaşı 53 idi. Sıgara içme dışında herhangi bir risk faktörleri yoktu. Hepsi depastörize süt ve süt ürünleri tüketmekteydi. 2 hastanınözgeçmişinde sistemik bruselloz vardı ve tedavi almışlardı. Hepsinde de baş ağrısı, halsizlik, iştahsızlık, bulantı, kusma, kilo kaybı, bel ağrısı gibi sistemik semptomlar vardı ama iskemik serebral semptomlardışında herhangi bir sistemik bruselloz bulguları yoktu. İkinci sıklıktaki nörolojik bulgu sensorinöral işitmekaybıydı. Kardiak embolizm, hiperkoagülabilite, vaskülermalformasyonlar, sistemik vaskülit ve enfektif endokardit dahil diğer TİA nedenleri ekarte edildi. NB tanısı BOS'ta Brucella'ya spesifik serolojik testler veya kültür ile kondu. Tüm hastalar trimetoprim-sulfametoksazol, doksisiklin ve rifampisinle en az 6 ay boyunca tedavi edildi. Tedavi başlandıktan sonra hiç birinde TİA tekrarı olmadı.TİA veya iskemik stroku olan genç hastalarda, özellikle de strok için risk faktörleri yoksa ve brusellozun sistemik olduğu bir bölgede yaşıyorlarsa, NB araştırılmalıdır. (Incidence of neurologic complications in systemic brucellosis has been reported as 2-10%. Neurobrucellosis (NB) can mimic many central and peripheral nervous system disorders including transient ischemic attacks (TIA), and ischemic or hemorrhagicstroke. We report a series of four cases presented with TIA or ischemic stroke as the predominant manifestation of NB. Three of the patients were 20-28 years of age, and one patient was 53 years old. They did not possess any stroke risk factors except for smoking. They all used to consume pasteurized milk or its products. Two patients hadsystemic brucellosis in the past and received antibiotic treatment. All of the patients had systemic symptomssuch as headache, fatigue, anorexia, nausea and vomiting, weight loss or lumbar pain, but no systemicsigns of brucellosis accompanying ischemic cerebral symptoms. The second most frequent neurological sign was sensorineural hearing loss. Other causes of TIA including cardiac embolism, hypercoagulability,vascular malformations, systemic vasculitis, and infective endocarditis were excluded. NB was diagnosed with serological tests or cultures for Brucella in CSF. All patients were treated with rimethoprimsulfamethoxazole,doxycycline and rifampicin for at least six months. None of them had any further TIA after the initiation of the treatment NB should always be sought in young patients with TIA or ischemic stroke, especially if they have no risk factors for stroke and live in an endemic area for brucellosis, even if they do not have other systemic signs of brucellosis.)
Haklar
Notlar

KaynakçaAl Deeb SM, Yaqub BA, Sharif HS, Phadke JG. Neurobrucellosis: Clinical characteristics, diagnosis, and outcome. Neurology 1989;39:498- 501.PMid:2927673Al-Orainey O, Laajam MA, Al-Aska AK, Rajapaske CN. Brucella meningitis. Journal of Infection 1987;14:141-145.
doi:10.1016/S0163-4453(87)91952-9
Anlar Y, Yalcin S, Secmeer G. Persistent hypoglycorrhachia in neurobrucellosis. The Ped Infect Dis J 1994;13:747-748.
doi:10.1097/00006454-199408000-00016
Bahemuka M, Shemena AR, Panayiotopoulus CP, Al-Aska AK, Obeid T, Daif AK. Neurological syndromes of brucellosis. J Neurol Neurosurg Psychiatry 1988;51:1017-1021.
doi:10.1136/jnnp.51.8.1017
PMid:50411Bashir R, Al-Kawi MZ, Harder EJ, Jinkins J. Nervous system brucellosis: diagnosis and treatment. Neurology 1985;35:1576-1581.PMid:3877254Bouza E, Garcia de la Torre M, Parras F, Guerrero A, Rodriguez-Creixems M, Gobernado J. Brucellar meningitis. Rev Infect Dis 1987;9:810-822.PMid:3326128Bucher A, Gaustad P, Pape E. Chronic neurobrucellosis due to Brucella melitensis. Scand J Infect Dis 1990;22:223-226.
doi:10.3109/00365549009037906
PMid:2356445Ceviker N, Baykaner K, Goksel M, Sener L, Alp H. Spinal cord compression due to brucella granuloma. Infection 1989;5:304-305.
doi:10.1007/BF01650713
Elrazak MA. Brucella optic neuritis. Arch Intern Med 1991;151:776-778.
doi:10.1001/archinte.151.4.776
PMid:2012464Espejo CED, Chaves FV, Ramis BS. Chronic intracranial hypertension secondary to neurobrucellosis. J Neurol 1987;234:59-61.
doi:10.1007/BF00314012
PMid:3819788Fincham RW, Sahs AL, Joynt RJ. Protean manifestations of nervous system brucellosis. JAMA 1963;184:269-275.PMid:19970029    PMCid:2062655Hansmann GH, Schenken JR. Melitensis meningoencephalitis. Mycotic aneurysm due to Brucella melitensis var porcine. Am J Pathol 1932;8:435-444.PMid:84703Larbrisseau A, Maravi E, Aguilera F, Martinez-Lage JM. The neurological complications of brucellosis. Can J Neurol Sci 1978;5:369-376.PMid:1420670McLean DR, Russell N, Khan MY. Neurobrucellosis: Clinical and theurapeutic features. Clin Infect Dis 1992;15:582-590.PMid:50411Molins A, Montalban J, Codina A. Parkinsonism in neurobrucellosis. J Neurol Neurosurg Psychiatry. 1987;50:1707-1708.
doi:10.1136/jnnp.50.12.1707-a
Mousa AM, Koshy TS, Araj GF, Marafie AA, Muhtaseb SA, Al-Mudallal DS, Busharetulla MS. Brucella meningitis: presentation, diagnosis and treatment-a prospective study of ten cases. Quarterly J Med 1986;233:873-885.Nelson-Jones A. Neurological complications of undulant fever. The clinical picture. Lancet 1951;1:495-498.
doi:10.1016/S0140-6736(51)91973-3
PMid:14869008Nichols E. Meningo-encephalitis due to brucellosis with the report of a case in which B. abortus was recovered from the cerebrospinal fluid, and review of the literature. Ann Intern Med 1951;35:673-693.PMid:3223223Pascual J, Combarros O, Polo JM, Barciano J. Localized CNS brucellosis: report of 7 cases. Acta Neurol 1988;78:282-289.
doi:10.1111/j.1600-0404.1988.tb03658.x
Roldan-Montaud A, Jimenez-Jimenez FJ, Zancada F, Molina-Arjona JA, Fernandez-Ballesteros A, Gutierrez-Vivas A. Neurobrucellosis mimicking migraine. Eur Neurol 1991;31:30-32.
doi:10.1159/000116631
PMid:2312754    PMCid:502231Sanchez-Sousa A, Torres C, Campello MG, Garcia C, Parras F, Cercenado E, Baquero F. Serological diagnosis of neurobrucellosis J Clin Pathol 1990;43:79-81.
doi:10.1136/jcp.43.1.79
PMid:3801851Shakir RA, Al-Din ASN, Araj GF, Lulu AR, Mousa AR, Saadah MA. Clinical categories of neurobrucellosis. A report on 19 cases. Brain 1987;110:213-223.
doi:10.1093/brain/110.1.213
PMid:3309909    PMCid:2418949Shakir RA. Neurobrucellosis. Postgrad Med J 1986;62:1077-1079.
doi:10.1136/pgmj.62.734.1077
Thomas R, Kameswaran M, Murugan V, Okafor BC. Sensorineural hearing loss in neurobrucellosis. The Journal of Laryngology and Otology 1993;107:1034-1036.
doi:10.1017/S0022215100125198
PMid:12238582Yilmaz M, Ozaras R, Ozturk R, Mert A, Tabak F, Aktuglu Y. Epileptic seizure: an atypical presentation in an adolescent boy with neurobrucellosis. Scand J Infect Dis 2002;34:623-625.
doi:10.1080/00365540210147561
PMid:13945207


Atıf Yapanlar

Gözat Sayfasına Dön

 

Sosyal Medya ve Araçlar

İstatistikler

  • Kayıt
    • Bu ay: 5
    • Toplam: 25513
  • Online
    • Ziyaretçi: 66
    • Üye: 0
    • Toplam: 66

Detaylı İstatistikler